Description
Product Specifications
COA
IFU
Instrument
Description
Carcinoembryonic antigen (CEA) describes a set of highly related glycoproteins involved in cell adhesion. CEA is normally produced in gastrointestinal tissue during fetal development, but the production stops before birth. Consequently, CEA is usually present at very low levels in the blood of healthy adults (about 2-4 ng/mL).[2] However, the serum levels are raised in some types of cancer, which means that it can be used as a tumor marker in clinical tests. These include cancers of the colon and rectum, prostate, ovary, lung, thyroid, or liver. High CEA levels may also be a sign of some noncancerous conditions, such as cirrhosis, noncancerous breast disease, and emphysema.
Product Specifications
Intended Use
Aurora Carcinoembryonic Antigen Assay is a chemiluminescent microparticle immunoassay (CMIA) for the quantitative determination of Carcinoembryonic Antigen (CEA) in human serum and plasma. The assay kit is intended for in vitro diagnostic use.
Principle
The Carcinoembryonic Antigen assay is a quantitative sandwich immunoassay to determine the presence of CEA in human serum and
plasma using CMIA technology with flexible assay protocols.
- Sample, and paramagnetic anti-CEA coated microparticles are mixed, CEA present in the sample binds to anti-CEA coated microparticles, forming an antigen antibody complex.
- After incubation, a conjugate containing acridinium-labeled anti-CEA is added to the reaction mixture and binds to unoccupied binding sites of the anti-CEA coated microparticles.
- After further incubation and washing, Pre-Trigger and Trigger Solutions are added to the reaction mixture.
- The resulting chemiluminescent reaction is measured as relative light units (RLUs). There is a relationship between the amount of CEA in the sample and the RLUs detected by the optical system. Results are calculated automatically based on the previously established calibration curve.
Storage
The kit should be stored upright, not upside down or horizontally. Store at 2–8°C with a validity period of 12 months.
COA
IFU
Instrument